Infographic image demonstrating how three stages can be simplified into a single step using 3M™ Harvest RC

Next-generation harvest technology

Single-step chromatographic purification at the harvest and clarification stages for recombinant protein therapeutic manufacturing

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Need help streamlining your process?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.

Next-generation bioprocessing

The newest 3M solution, 3M™ Harvest RC, utilizes fibrous anion exchange (AEX) chromatography to efficiently separate cells, cell debris and DNA from the harvest fluid containing the target product. Precision quaternary ammonium (Q) functionalized polypropylene fiber, combined with a 0.2 µm PES membrane, provides predictable clarification that is scalable from discovery to commercial manufacturing.

Next-generation process

Quality and reliability

3M™ Harvest RC enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

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3M™ Harvest RC
  •     Removes soluble and insoluble contaminants
  •     Turbidity reduction from >2000 to <15 NTU
  •     High mAb recovery, >95%

 

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Cost-efficient and compact

3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses and other negatively charged contaminants in flow-through polishing chromatography.

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Sign up for a virtual trial of 3M Harvest RC

Learn how to set up experiments for implementing 3M Harvest RC in your upstream process. Sign up for a virtual trial with a 3M application engineer.

Innovative design and performance

3M Harvest RC enables a single-stage clarification process of low- to high-density cell culture (> 40 million cells per mL) with high recovery, and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.

  • Thumbnail image of article written on the topic of Key Trends
    Key Trends Reshaping the Future of Bio-Pharmaceutical Harvest & Clarification
    Cell harvesting and clarifications are both crucial steps that can have a significant impact on the design of downstream processes. As processes change upstream in the pharmaceutical manufacturing workflow, causing variability of cell culture fluid, downstream purification unit operations will be impacted.
  • Thumbnail image of white paper written by Frost and Sullivan
    3M Harvest RC: Powering Single Stage Clarification

    Read an analysis by Frost & Sullivan on how 3M Harvest RC transforms the clarification process by replacing centrifuge and depth filtration steps, improves process efficiencies and scales effectively with a wide range of product formats.

  • Thumbnail image from Frost and Sullivan on the topic of Next Generation Harvest techniques
    A Frost & Sullivan Perspective on Next Generation Harvest Techniques

    Academic and industry leaders in biopharmaceutical manufacturing participated in a  thought leadership forum, the Virtual Think Tank series, to discuss challenges, strategies, techniques, and barriers to new technology implementation in monoclonal antibody harvesting.

  • Thumbnail image of white paper written by Frost and Sullivan
    3M Harvest RC: Re-imagining Clarification

    Read a Frost & Sullivan analysis of how 3M Harvest RC re-imagines the clarification process to address challenges posed by global biologics trends.


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Designed to advance bioprocessing

Simplify three stages into a single step.

Infographic image demonstrating how three stages can be simplified into a single step using 3M™ Harvest RC

Need help finding the right bioprocessing product?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.