3M™ Zeta Plus™ VR Series Filter Cartridge, 4510911 VR06, 8 in x 6.7 in, 8 cell, Nitrile, 15/Case
- 3M ID 70020109008
Details
Highlights
- With specific biological fluids, combined anion exchange and physical entrapment removal mechanisms provides an added level of viral reduction
- Depth filtration with anion exchange capacity helps protect chromatography columns or function as a prefilter to a size exclusion virus removal membrane filter
- Quality release testing includes a media ion exchange capacity assay
- A range of scalable cartridge sizes and sanitary housings enables predictable performance at every stage of drug development
We designed Zeta Plus™ VR Series filter cartridges to help the reduction of certain viruses from biological fluids. They provide viral reduction at high flow rates in scalable cartridge configurations. Backed by our quality control testing, these products are designed for applications in biological and pharmaceutical filtration.
The removal and/or inactivation of contaminating viruses from biotherapeutics is a regulatory requirement for helping to ensure final product safety. A range of scalable cartridge sizes and sanitary housings enables predictable performance at every stage of drug development from early stage discovery to commercial production Zeta Plus depth filtration offers an economical approach to enhance the performance of other technologies for reduction of certain types of viruses.
Our Zeta Plus VR Series filter media comprises a mixture of high surface area inorganic particles, cellulose, and a positively charged crosslinking polymer. This positive charge enhanced depth filtration combines mechanical entrapment and anion exchange for improved removal of many negatively charged containments. Depth filtration with anion exchange capacity helps protect chromatography columns or function as a prefilter to a size exclusion virus removal membrane filter.
Zeta Plus™ VR Series cartridges are constructed from multiple lenticular cells of opposing media discs bonded together with molded edge seals then assembled with polypropylene seals between each cell and unitized with stainless steel bands. Cartridges and sanitary housings are available in 8”, 12”, and 16” diameter enabling predictable scale-up to full scale production.
Pharmaceutical Grade Product
The Zeta Plus™ VR Series Filter Cartridges are designed for use in biological applications where virus reduction is desired. The effluent characteristics of the Zeta Plus VR Series Filter media has been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia. All components of construction including the filtration media have been tested to demonstrate compliance to USP <88> Class VI Biological Reactivity, in-vivo. These results are documented in an available Regulatory Support File.
The 3M Purification Inc. Quality Management System is approved by an accredited registering body to the ISO 9001:2008 and ISO 13485:2003 Quality Management Systems. The manufacturing process, quality controls and regulatory oriented compliance reports are documented in a Drug Master File on record with the FDA. Every manufacturing lot of Zeta Plus VR Series media is quality release tested for ion exchange capacity using a charged dye.
Specifications
